Phosphorus Intake and Potential Dietary Influences Examined via 24-Hour Urinary Biomarker Measurements in German Children and Adolescents Over 3 Decades.

BACKGROUND: Increases in phosphorus intake have been observed over the past years in adult populations. However, biomarker-based data are lacking on whether or not phosphorus intake also increased in children. OBJECTIVE: The aim of this study was to examine 24-hour urinary phosphate excretion (PO4-Ex) and diet-related biomarkers potentially influencing phosphorus status in German children and adolescents from 1985 to 2015. DESIGN: This longitudinal noninvasive biomarker-based cohort study examined 24-hour urine samples from children and adolescents of the Dortmund Nutritional and Anthropometric Longitudinally Designed Study, collected over 3 decades. PARTICIPANTS/SETTING: Examined individuals (n = 1,057) were healthy participants of the Dortmund Nutritional and Anthropometric Longitudinally Designed Study, situated in Dortmund, Germany, who had been asked to collect one yearly 24-hour urine sample. Six thousand seven hundred thirty-seven samples collected from participants aged 3 to 17 years between 1985 (baseline) and 2015, were included. MAIN OUTCOME MEASURES: phosphorus intake was examined biomarker-based by analyzed PO4-Ex in 24-hour urine samples. Whether acid-base status and intakes of protein, salt, and fruits and vegetables, may have relevantly contributed to PO4-Ex levels was assessed by determining 24-hour excretions of net acid, urea-nitrogen, and sodium as well as specific standardized excretions of potassium plus oxalate. STATISTICAL ANALYSES PERFORMED: Trend analysis over 30 years and potentially influencing diet factors were examined using linear mixed-effect regression models (PROC-MIXED). Adjustments for sex, age, and body surface area were performed. RESULTS: No change was identifiable for PO4-Ex over the 3 decades; neither in 3 to 8, 9 to 13, nor in 14 to 17 year olds. However, sodium excretion increased (P = .001). PROC-MIXED analysis on intraindividual changes in PO4-Ex revealed direct relationships with net acid excretion, urea-nitrogen, and sodium excretion and an inverse relationship with a biomarker of fruit and vegetable intake. CONCLUSIONS: Despite a direct relationship between PO4-Ex and a biomarker of industrially processed food consumption; that is, sodium excretion, which showed an increasing time trend, phosphorus intake was found to remain stable over decades in children and adolescents.

Higher Renal Net Acid Excretion, but Not Higher Phosphate Excretion, during Childhood and Adolescence Associates with the Circulating Renal Tubular Injury Marker Interleukin-18 in Adulthood.

High dietary phosphorus intake (P-In) and high acid loads may adversely affect kidney function. In animal models, excessive phosphorus intake causes renal injury, which, in humans, is also inducible by chronic metabolic acidosis. We thus examined whether habitually high P-In and endogenous acid production during childhood and adolescence may be early indicators of incipient renal inflammatory processes later in adulthood. P-In and acid-base status were longitudinally and exclusively determined by biomarker-based assessment in 277 healthy children, utilizing phosphate and net acid excretion (NAE) measurements in 24 h urine samples repeatedly collected between the ages of 3 and 17 years. Standard deviation scores (by sex and age) were calculated for anthropometric data and for the urinary biomarkers available within age range 3-17 years. Multivariable linear regression was used to analyze the relations of phosphate excretion and NAE with the adulthood outcome circulating interleukin-18 (IL-18), a marker of inflammation and kidney dysfunction. After adjusting for growth- and adulthood-related covariates and pro-inflammatory biomarkers to rule out confounding by non-renal inflammatory processes, regression models revealed a significant positive relationship of long-term NAE (p = 0.01), but not of long-term phosphate excretion with adult serum IL-18. Similar significant positive regression results were obtained after replacing NAE with 24 h urinary ammonium excretion as the exposition variable. Our results suggest that even moderate elevations in renal ammonia production, as caused by habitually higher acid loading during growth, may affect the intrarenal pro-inflammatory system in the long-term, known to be boosted by acidosis-induced raised ammoniagenesis.

Qualidade da dieta de idosas não institucionalizadas de uma capital do sul do Brasil: baixo consumo de gorduras saturadas, sódio, cereais integrais e de gorduras cardioprotetoras / Diet quality ofnon-institutionalized elderly women from a Brazilian southern capital city: low consumption of saturated fats, sodium, whole grains, and cardioprotective fats

Introdução:A população idosa é suscetível às alterações no estado nutricional devido aos fatores relacionados às modificações socioeconômicas e fisiológicas; porém, estudos que avaliaram a situação alimentar atual de idosos no Brasil ainda são escassos. Objetivo: Avaliar a qualidade da dieta de idosas não institucionalizadas de uma capital do sul do Brasil. Métodos: Trata-se de um estudo de caráter transversal, com 174 idosas selecionadas por conveniência. A avaliação do consumo alimentar foi realizada por meio de registro alimentar de três dias. Avaliou-se a qualidade da dieta por meio do Índice de Qualidade da Dieta ­ Revisado (IQD-R) adaptado para a população brasileira.Resultados: Verificou-seque56,9% (n=99), 40,8% (n=71) e 2,3% (n=4) das participantes apresentaram dieta que "necessita de modificação", dieta "saudável", e dieta "inadequada", respectivamente. A pontuação média obtida por meio do IQD-R foi de 62,5 (± 9,6), com mínimo de 30,2 pontos e máximo de 84,9 pontos.Na análise do consumo dos grupos alimentares, constatou-se baixa pontuação de gordura saturada (9,96±0,50), mono e poli-insaturada (1,08±2,21), cereais integrais (1,7±1,54), sódio (7,31±2,27), e maior pontuação para o grupo de cereais totais (4,61±0,54).Conclusão: A maioria das idosas avaliadas necessitam de melhoria na qualidade da dieta, com ênfase no consumo de cereais integrais e gorduras mono e poli-insaturadas, porém com ingestão adequada de gordura saturada e sódio.

Introduction: The elderly population is susceptible to changes in nutritional status due to factors related to socioeconomic and physiological changes; however, studies that evaluated the current dietary status of the elderly in Brazil are still scarce. Objective: To evaluate the quality of the diet of non-institutionalized elderly women from a capital city in southern Brazil. Methods: This was a cross-sectional study, with 174 convenience sampled elderly women. Food intake was assessed by means of a three-day dietary record. Diet quality was assessed through the Diet Quality Index - Revised (IQD-R) adapted for the Brazilian population. Results: This work showed that 56.9% (n=99), 40.8% (n=71), and 2.3% (n=4) of the diets of the participants were classified as "needs modification", "healthy", and "inadequate", respectively. The mean score obtained through the IQD-R was 62.5 (± 9.6), with a minimum of 30.2 points and a maximum of 84.9 points. In the analysis of food group consumption, there was a low score for saturated fat (9.96±0.50), mono and polyunsaturated fats (1.08±2.21), whole grains (1.7±1.54), sodium (7.31±2.27), and a higher score for the total grains group (4.61±0.54). Conclusion: Most of the elderly women assessed needed improvement in the quality of their diets, with emphasis on the consumption of whole grains and mono and polyunsaturated fats, but with adequate intake of saturated fat and sodium.